Endocrine Abstracts

Background: Evaluation of plantar pressure is useful for detecting functional abnormality of foot, especially in diabetic patients. The aim of this study was to evaluate plantar pressure and force in diabetic patients using Tekscan F-Scan in-shoe foot force and gait analysis system.Methods: Plantar pressure and force were measured by selecting an area of interest under the six areas of the foot: hallux, first metatarsal, second metatarsal, 3–5 metat...

The combination of hypoparathyroidism, sensorineural deafness and renal dysplasia, named HDR syndrome, is a rare disease. Heterozygous abnormalities of GATA3 gene are associated with this syndrome. Here we report a novel heterozygous mutation, c.255_256ins4 (GTGC), in GATA3 gene. A 41-year-old man was diagnosed as having idiopathic hypoparathyroidism and has been treated with 1α-hydroxyvitamin D3 and calcium carbonate. Three years later, he had a hearing...

Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2Excessive vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis and restenosis. On the other hand, apoptosis of VSMCs accelerates plaque rupture in the atherosclerotic vessels. Therefore, a strategy that regulates both VSMC proliferation and apoptosis is essential for the development of new pharmacologica...

Background: Postsurgical hypocalcemia is the most common and most troubling long-term consequence of thyroidectomy. In this study, we investigated the potential role of routine calcium or vitamin D supplementation in preventing postsurgical hypoparathyroidism.Methods: We carried out a systematic search of MEDLINE and EMBASE for English-language publications using the keywords “calcium”, “vitamin D”, and “thyroid cancer&#8221...

Programmed cell death-1 (PD-1) receptor inhibitor is an immune check point blockade for anticancer treatment and is currently used for various malignancies such as melanoma, non-small cell lung cancer, and so on. However, an immune check point blockade is associated with a risk for immune related adverse events. Among these events, Type 1 diabetes is rare. We present a case of a 52-year-old man, with no previously diabetic history, who developed diabetic ketoacidosis (DKA) aft...

Addison’s disease is most commonly caused by autoimmune adrenalitis. But, adrenal tuberculosis is still major cause in developing countries, that usually caused by hematogenous spread of pulmonary tuberculosis. Systemic tuberculosis causing Addison’s disease has been rarely reported. We present a case of Addison’s disease caused by systemic disseminated tuberculosis which was mimicked as lymphoma on F-18 FDG PET-CT (PET-CT).Sixty eight-yea...

Our goal is to better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases in order to facilitate improved diagnosis, treatment, and family counselling. LIM-homeodomain transcription factors regulate many aspects of development and mutations in the genes that encode these regulatory proteins are associated with several diseases. The LHX3 LIM-homeodomain protein is critical for pituitary gland organogenesis and some nervous s...

Atypical manifestations of hyperthyroidism include hematological, cardiovascular, dermatological manifestation. Especially single lineage abnormalities such as anemia (34%), leukopenia (5.8%), thrombocytopenia (3.3%) are reported, but pancytopenia is a rare presentation of hyperthyroidism. The suspected etiologic mechanisms include ineffective hematopoiesis, reduction in blood cell life span, autoimmune process, toxicity of thyroid hormone.We report a ca...

Background: The predictive ability of prediabetes defined by HbA1c (5.7–6.4%) or fasting plasma glucose (FPG) criteria (5.6–6.9 mmol/l) for the development of diabetes may differ according to ethnic groups, but only limited longitudinal data are available in Asians. We examined the progression rate to diabetes in Korean adults diagnosed as prediabetes according to these two criteria.Methods: We analyzed data of 9432 Korean adults (age 20–7...

The class of endocrine disrupting chemicals (EDCs) is comprised of both naturally occurring and man-made compounds which are structurally similar or distinct to estrogen, and can interfere with the actions of an endogenous steroid hormone via estrogen receptors (ERs). Octylphenol (OP) is alkyl phenol chemical, which is considered to be a low-level endocrine disruptor owing to its tendency to mimic estrogen. It has been reported that triclosan can cause endocrine disruption and...